COVID-19 and Role of Cinchona officinalis (Cinchona
Bark)
Ayurvedic Herb and Homeopathic Drug
China - A Matter of Research
Corona Virus Disease or COVID-19 - that is an RNA protein and
covered by a protective layer of lipid and the shape is like a Crown (Spike).
Since the MHFW ordered manufacturing of Hydroxychloroquine (HCQ). Chloroquine
and Hydroxychloroquine are having the structural formulae as
Structure
of Chloroquine C18H32C1N3O8P2
Hydroxychloroquine(HCQ
) C18H26C1N30.H2SO4
Structure
of Quinine C20H24N202
Cinchono Bark or Cinchona Chaal
Cinchona officinalis is a medicinal plant, and Cinchona officinalis is used for the
production of Quinine, which is an anti-fever agent. It is
especially useful in the prevention and treatment of Malaria. Other alkaloids that are extracted from this tree
include Cinchonine, Cinchonidine , Quinidine and
the major substances among over thirty others (Mc Calley 2002).
Mechanism of Action
Quinine accumulates in the Lysosomes of
the malarial parasites and interferes with essential processes ultimately
leading to the death of the parasites. Quinine is effective in malaria caused
by Plasmodium vivax, Plasmodium malariae and Plasmodium
ovale.
Quinine acts as a blood schizonticide although it also
has gametocytocidal activity against P. vivax and P. malariae. Because it is a
weak base, it is concentrated in the food vacuoles of P. falciparum. It is
thought to act by inhibiting heme polymerase, thereby allowing accumulation of
its cytotoxic substrate, heme. As a schizonticidal drug, it is less effective
and more toxic than chloroquine. However, it has a special place in the
management of severe falciparum malaria in areas with known resistance to
chloroquine.
The theorized mechanism of action for quinine and related
anti-malarial drugs is that these drugs are toxic to the malaria parasite.
Specifically, the drugs interfere with the parasite's ability to break down and
digest hemoglobin. Consequently, the parasite starves and/or builds up toxic
levels of partially degraded hemoglobin in itself.
China officinalis was the first remedy proved
by Dr Samuel Hahnemann. It is therefore a very important remedy in the history
of homeopathy, and consequently it is one of the first that aspiring homeopaths
study.
Can we use China in its different
strength as a curative as well as prophylactic to coup with Covid-19, is a
matter of clinical trials for Homeopaths.
On the other
hand, concoction of Cinchona bark is used as a drug in the treatment of Malaria
fever for several years by Ayurveda Physicians.
Since, Cinchona
officinalis was used widely both by Ayurveda and Homeopathic system of
medicines. Cinchona Bark concoction (Syrup or Powder) or
China Homeopathic drug be considered as Prophylactic and curative along with
Allopathic line of treatment with the help of eminent researchers to cure this
dreaded debase COVID -19.
Its high time to use alternative system of Medicines along with Allopathic line of treatment as holistic approach to cure this dreaded COVID-19.
Even a latest study on COVID19 has shown that Ramidiviris has good results in treating COVID19 patients.
Ramidivir Molecular Formula C27H35N6O8P
Chloroquine Molecular Formula C18H32C1N3O8P2
The above formulae are very much similar except carbon. The chloroquine, if used clinically by researchers might have promising results in curing corona and cost effective as well .
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